The advent of regenerative medicine has brought us the opportunity to regenerate, modify
and restore human organs function. Stem cells, a key resource in regenerative medicine, are …

S100B belongs to a multigenic family of Ca2+‐binding proteins of the EF‐hand type and is
expressed in high abundance in the brain. S100B interacts with target proteins within cells …

Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors
to the primary cilium. Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have …

Glioblastoma (GBM) is a highly lethal brain tumour presenting as one of two subtypes with
distinct clinical histories and molecular profiles. The primary GBM subtype presents acutely …

The role of the cell surface CD133 as a cancer stem cell marker in glioblastoma (GBM) has
been widely investigated, since it identifies cells that are able to initiate neurosphere growth …

Neuroinflammation and endoplasmic reticulum (ER) stress are associated with many
neurological diseases. Here, we have examined the interaction between ER stress and …

In human glioblastomas (hGBMs), tumor-propagating cells with stem-like characteristics
(TPCs) represent a key therapeutic target. We found that the EphA2 receptor tyrosine kinase …

Background We report the initial results from a phase I clinical trial for ALS. We transplanted
GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the …

Glioblastomas display cellular hierarchies containing tumor-propagating glioblastoma stem
cells (GSCs). STAT3 is a critical signaling node in GSC maintenance but molecular …

A hallmark feature of glioblastoma is its strong self-renewal potential and immature
differentiation state, which contributes to its plasticity and therapeutic resistance. Here …