The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER
protein homeostasis is essential for the coordination of its diverse functions and depends on …

The ATP-driven chaperone valosin-containing protein (VCP)/p97 governs critical steps in
ubiquitin-dependent protein quality control and intracellular signalling pathways. It …

Proteins that fail to correctly fold or assemble into oligomeric complexes in the endoplasmic
reticulum (ER) are degraded by a ubiquitin-and proteasome-dependent process known as …

Protein folding is a complex, error-prone process that often results in an irreparable protein
by-product. These by-products can be recognized by cellular quality control machineries …

The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic
proteome and is accordingly endowed with specialized machinery to ensure that proteins …

p97/VCP (known as Cdc48 in S. cerevisiae or TER94 in Drosophila) is one of the most
abundant cytosolic ATPases. It is highly conserved from archaebacteria to eukaryotes. In …

Abstract p97 (also known as Cdc48, Ter94, and VCP) is an essential, abundant and highly
conserved ATPase driving the turnover of ubiquitylated proteins in eukaryotes. Even though …

Protein homeostasis deficiencies underlie various cancers and neurodegenerative
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …

The endoplasmic reticulum (ER) serves as a warehouse for factors that augment and control
the biogenesis of nascent proteins entering the secretory pathway. In turn, this compartment …

The AAA+ (ATPases associated with diverse cellular activities) ATPase p97 is essential to a
wide range of cellular functions, including endoplasmic reticulum-associated degradation …