Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …

The emergence and spread of antibiotic resistance is one of the biggest challenges in public
health. There is an urgent need to discover novel agents against the occurrence of multidrug …

Macrophages are heterogeneous and their phenotype and functions are regulated by the
surrounding micro‐environment. Macrophages commonly exist in two distinct subsets: 1) …

Antibiotic treatment failure is of growing concern. Genetically encoded resistance is key in
driving this process. However, there is increasing evidence that bacterial antibiotic …

Approximately 10% of antimicrobials used by humans in low-and middle-income countries
are estimated to be substandard or falsified. In addition to their negative impact on morbidity …

The design and production of an oral dual-compartmental dosage unit (dcDU) was
examined in vitro and in vivo with the purpose of physically isolating and modulating the …

Tuberculosis (TB) recently became the leading infectious cause of death in adults, while
attempts to shorten therapy have largely failed. Dormancy, persistence, and drug tolerance …

Tuberculosis (TB) is the ninth cause of global death, more than any other infectious disease.
With growing drug resistance the epidemic remains and will require significant attention and …

Abstract In this study Fusion Deposition Modelling (FDM) was employed to design and
fabricate a bilayer tablet consisting of isoniazid (INZ) and rifampicin (RFC) for the treatment …

Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), is an extremely
successful pathogen that adapts to survive within the host. During the latency phase of …