Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in
normal tissues, making most subtypes unsuitable as targets for cancer therapy. However …

Gangliosides are a large subfamily of glycosphingolipids that broadly exist in the nervous
system and interact with signaling molecules in the lipid rafts. GD3 and GD2 are two types of …

Ovarian cancer is a malignant disease that affects thousands of patients every year.
Currently, we use surgical techniques for early-stage cancer and chemotherapy treatment …

Sphingolipids, crucial components of cellular membranes, play a vital role in maintaining
cellular structure and signaling integrity. Disruptions in sphingolipid metabolism are …

Gangliosides have been considered to modulate cell signals in the microdomain of the cell
membrane, lipid/rafts, or glycolipid-enriched microdomain/rafts (GEM/rafts). In particular …

Colorectal cancer (CRC) is one of the most important malignancies and causes of cancer-
related deaths worldwide. Cancer stem cell markers identification could be helpful to acquire …

Background Triple-negative breast cancer (TNBC) is the most aggressive breast cancer
subtype with no effective standard therapy. Breast cancer stem-like cells (BCSCs) in primary …

Abstract Purpose: Medulloblastoma (MB), the most common childhood malignant brain
tumor, has a poor prognosis in about 30% of patients. The current standard of care, which …

Metaplastic breast carcinoma (MBC) is a rare breast cancer subtype with rapid growth, high
rates of metastasis, recurrence and drug resistance, and diverse molecular and histological …

Treatment of metastasized or recurrent oral (OSCC) and oropharyngeal (OPSCC) squamous
cell carcinoma remains challenging. Targeted antibody-based therapy inter alia for PD-1/PD …