The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture,
vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Because of their rare detection in atherosclerotic lesions, the involvement of neutrophils in
the pathophysiology of atherosclerosis has been largely denied. However, over the past …

Atherosclerosis underlies most cardiovascular diseases, and is accepted as a primary cause
of mortality worldwide. Proteases have been implicated in the development and progression …

Understanding the pathophysiology of atherogenesis and the progression of atherosclerosis
have been major goals of cardiovascular research during the previous decades. However …

Matrix metalloproteinases (MMPs) are a large family of zinc-endopeptidases which play
important roles in multiple physiological and pathological processes. These enzymes are …

Matrix metalloproteinases (MMPs) have outgrown the field of extracellular-matrix biology
and have progressed towards being important regulatory molecules in cancer and …

Most acute cardiovascular events are due to plaque rupture, with atheromas containing
large necrotic cores and thin fibrous caps being more susceptible to rupture and lesions with …

The formation of atherosclerotic plaques in the large and medium sized arteries is classically
driven by systemic factors, such as elevated cholesterol and blood pressure. However, work …