Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation

M Kropp, O Golubnitschaja, A Mazurakova… - Epma Journal, 2023 - Springer
Proliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent
complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age …

Diabetic retinopathy: pathophysiology and treatments

W Wang, ACY Lo - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy (DR) is the most common complication of diabetes mellitus (DM). It has
long been recognized as a microvascular disease. The diagnosis of DR relies on the …

Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets

S Nian, ACY Lo, Y Mi, K Ren, D Yang - Eye and Vision, 2021 - Springer
Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading
cause of visual loss in working-age individuals in many industrialized countries. It has been …

Lutein supplementation for eye diseases

LH Li, JCY Lee, HH Leung, WC Lam, Z Fu, ACY Lo - Nutrients, 2020 - mdpi.com
Lutein is one of the few xanthophyll carotenoids that is found in high concentration in the
macula of human retina. As de novo synthesis of lutein within the human body is impossible …

Terpenoids as potential geroprotectors

E Proshkina, S Plyusnin, T Babak, E Lashmanova… - Antioxidants, 2020 - mdpi.com
Terpenes and terpenoids are the largest groups of plant secondary metabolites. However,
unlike polyphenols, they are rarely associated with geroprotective properties. Here we …

Nutraceuticals for the treatment of diabetic retinopathy

MG Rossino, G Casini - Nutrients, 2019 - mdpi.com
Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus and
is characterized by degeneration of retinal neurons and neoangiogenesis, causing a severe …

The colorful world of carotenoids: A profound insight on therapeutics and recent trends in nano delivery systems

S Maghsoudi, B Taghavi Shahraki… - Critical reviews in …, 2022 - Taylor & Francis
The therapeutic effects of carotenoids as dietary supplements to control or even treat some
specific diseases including diabetic retinopathy, cardiovascular diseases, bacterial …

Nutraceuticals: a promising therapeutic approach in ophthalmology

CR Castro-Castaneda, F Altamirano-Lamarque… - Nutrients, 2022 - mdpi.com
Oxidative stress represents one of the main factors driving the pathophysiology of multiple
ophthalmic conditions including presbyopia, cataracts, dry eye disease (DED), glaucoma …

The protective effects of flavonoids and carotenoids against diabetic complications—A review of in vivo evidence

Y Jin, R Arroo - Frontiers in Nutrition, 2023 - frontiersin.org
Diabetes mellitus is a chronic metabolic disorder caused either by inadequate insulin
secretion, impaired insulin function, or both. Uncontrolled diabetes is characterized by …

Nutritional and medical food therapies for diabetic retinopathy

C Shi, P Wang, S Airen, C Brown, Z Liu, JH Townsend… - Eye and Vision, 2020 - Springer
Diabetic retinopathy (DR) is a form of microangiopathy. Reducing oxidative stress in the
mitochondria and cell membranes decreases ischemic injury and end-organ damage to the …