The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is
exploited as a target for the design of antibiotics. This pathway culminates in the production …

Spirocyclic pyrrolidines are structural motifs frequently found in a wide variety of natural
products, pharmaceuticals and biologically significant compounds. In the past few years …

Introduction: Rhodanine-based compounds have been associated with numerous biological
activities. After many years of research in drug discovery, they have gained a reputation as …

Many biological activities originate from interactions between small-molecule ligands and
their protein targets. A detailed structural and physico-chemical characterization of these …

The widespread emergence of resistant bacterial strains is becoming a serious threat to
public health. This thus signifies the need for the development of new antibacterial agents …

In search of new active molecules against Mycobacterium tuberculosis (MTB) H37Ra and
Mycobacterium bovis BCG, a small focused library of rhodanine incorporated …

To tackle leishmaniasis, search for efficient therapeutic drug targets should be pursued.
Dihydrofolate reductase (DHFR) is considered as a key target for the treatment of …

A series of rhodanine incorporated quinoline derivatives were efficiently synthesized using
reusable DBU acetate as ionic liquid and evaluated for their in vitro antitubercular activity …

The emergence of Multidrug Resistance (MDR) strains of bacteria has accelerated the
search for new antibacterials. The specific bacterial peptidoglycan biosynthetic pathway …

A highly efficient asymmetric 1, 3-dipolar cycloaddition of azomethine ylides to 5-alkylidene
thia (oxa) zolidine-2, 4-diones catalyzed by a chiral N, O-ligand/Cu (CH3CN) 4BF4 system is …