Desmoplakin Cardiomyopathy: Role of Inflammation and Potential Role of Disease-Modifying Therapies

A Gasperetti, RT Carrick, S Muller, B Murray… - Current Cardiology …, 2025 - Springer
Abstract Purpose of Review To summarize the available data on the use of
immunosuppression therapies for the management of hot phases of disease and recurrent …

Ventricular discordance as an MRI phenotype provides prognostic value among arrhythmogenic cardiomyopathy

JY Xiang, Y Zhao, WH Xie, DA An… - Journal of Magnetic …, 2024 - Wiley Online Library
Background In arrhythmogenic cardiomyopathy (ACM), left ventricle‐dominant presentation
has poorer outcomes than right‐dominant presentation, suggesting that interventricular …

Arrhythmogenic Cardiomyopathy: Towards Genotype Based Diagnoses and Management

SA Muller, G Bertoli, J Wang… - Journal of …, 2024 - Wiley Online Library
Arrhythmogenic cardiomyopathy (ACM) is a genetically heterogeneous inherited
cardiomyopathy with an estimated prevalence of 1: 5000–10 000 that predisposes patients …

Sudden cardiac death risk stratification in heritable cardiomyopathies: phenotype-based to genotype-based risk scores

R Tadros - European Heart Journal, 2024 - academic.oup.com
Phenotype-and genotype-based risk stratification of ventricular arrhythmia (VA) in patients
with heritable cardiomyopathy and no prior sustained VA events. Risk scores are highlighted …

Performance of ARVC Risk Calculators in (Likely) Pathogenic Plakophilin-2 Variant Carriers Without Definite ARVC Diagnosis

SA Muller, B Asatryan, B Murray, C Tichnell… - Circulation …, 2024 - ahajournals.org
Sustained VA was defined as a composite of sudden cardiac death or sudden cardiac arrest,
spontaneous sustained VT (VT lasting≥ 30 s at≥ 100 bpm and with hemodynamic …

Lifetime cumulative activity burden is associated with symptomatic heart failure and arrhythmic risk in patients with arrhythmogenic right ventricular cardiomyopathy: a …

L Binzenhöfer, S Clauss, K Strauß, J Höpler, M Kraft… - Europace, 2024 - academic.oup.com
Aims Sports-related physical activity is associated with an increased risk of ventricular
dysfunction and arrhythmias in patients with arrhythmogenic right ventricular …

Naxos Disease and Related Cardio-Cutaneous Syndromes

A Protonotarios, A Asimaki, C Basso, Z Xylouri… - JACC: Advances, 2025 - jacc.org
Naxos disease is a rare autosomal recessive condition combining arrhythmogenic right
ventricular cardiomyopathy, woolly hair, and palmoplantar keratoderma. The first identified …

Endurance Exercise Promotes Episodes of Myocardial Injury in Individuals with a Pathogenic Desmoplakin (DSP) Variant

AP Jacobsen, K Chiampas, SA Muller, A Gasperetti… - Heart Rhythm, 2024 - Elsevier
Background Desmoplakin (DSP) variants are associated with left-predominant or
biventricular arrhythmogenic cardiomyopathy. Exercise promotes penetrance and sustained …

Genetic testing in cardiomyopathies and new therapeutic target in cardiac remodelling

F Crea - European Heart Journal, 2025 - academic.oup.com
Perry Elliott from the University College London in the UK. 1 The authors point out that in the
modern era, cardiologists managing patients and families with cardiomyopathies need to be …

Hot topics in thromboembolic risk prevention, heart failure monitoring, and cardiomyopathy risk stratification

F Crea - European Heart Journal, 2024 - academic.oup.com
Landmesser from the Deutsches Herzzentrum der Charite in Berlin, Germany, and
colleagues. 1 The authors remind us that atrial fibrillation (AF) is associated with an …