Abstract Background Mutation of the Duchenne muscular dystrophy (DMD) gene causes
Duchenne and Becker muscular dystrophy, degenerative neuromuscular disorders that …

Recently, we and others identified the microRNA miR-34a as a target of the tumor
suppressor gene product p53. Ectopic miR-34a induces a G1 cell cycle arrest, senescence …

Many common human mesenchymal tumors, including gastrointestinal stromal tumor (GIST),
rhabdomyosarcoma (RMS) and leiomyosarcoma (LMS), feature myogenic differentiation …

Dystrophin is an essential muscle protein that contributes to cell membrane stability by
mechanically linking the actin cytoskeleton to the extracellular matrix via an adhesion …

Progressive meningiomas that have failed surgery and radiation have a poor prognosis and
no standard therapy. While meningiomas are more common in females overall, progressive …

Genome rearrangements have long been recognized as hallmarks of human tumors and
have been used to diagnose cancer. Techniques used to detect genome rearrangements …

Olfactory neuroblastoma (ONB) is a rare malignant neoplasm arising in the upper portion of
the sinonasal cavity. To better understand the genetic bases for ONB, here we perform …

Meningiomas are the most common primary intracranial neoplasm with diverse pathological
types and complicated clinical manifestations. The fifth edition of the WHO Classification of …

Albeit genetically highly heterogeneous, muscular dystrophies (MDs) share a convergent
pathology leading to muscle wasting accompanied by proliferation of fibrous and fatty tissue …

DMD gene mutations have been associated with the development of Dystrophinopathies.
Interestingly, it has been recently reported that DMD is involved in the development and …