Several neurodegenerative disorders involve impaired neurotransmission, and glutamatergic neurotransmission sets a prototypical example. Glutamate is a predominant …
C Zhou, X Chen, R Planells-Cases, J Chu, L Wang… - Immunity, 2020 - cell.com
The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and malignant cells and catalyzes the formation of 2′ 3′ cGMP-AMP (cGAMP), which in turn …
FK Voss, F Ullrich, J Münch, K Lazarow, D Lutter… - Science, 2014 - science.org
Regulation of cell volume is critical for many cellular and organismal functions, yet the molecular identity of a key player, the volume-regulated anion channel VRAC, has remained …
Membrane transport is a fundamental means to control basic cellular processes such as apoptosis, inflammation, and neurodegeneration and is mediated by a number of …
L Seminario-Vidal, SF Okada, JI Sesma… - Journal of Biological …, 2011 - ASBMB
ATP released from airway epithelial cells promotes purinergic receptor-regulated mucociliary clearance activities necessary for innate lung defense. Cell swelling-induced …
H Gaitán-Peñas, A Gradogna, L Laparra-Cuervo… - Biophysical journal, 2016 - cell.com
Volume-regulated anion channels (VRACs) play an important role in controlling cell volume by opening upon cell swelling. Recent work has shown that heteromers of LRRC8A with …
J Sikora, SN Orlov, K Furuya… - Blood, The Journal of …, 2014 - ashpublications.org
The hypothesis that regulated ATP release from red blood cells (RBCs) contributes to nitric oxide-dependent control of local blood flow has sparked much interest in underlying release …
AA Mongin - Pflügers Archiv-European Journal of Physiology, 2016 - Springer
The volume-regulated anion channel (VRAC) is a ubiquitously expressed yet highly enigmatic member of the superfamily of chloride/anion channels. It is activated by cellular …
Cell volume regulation (CVR) is essential for all types of cells in the central nervous system (CNS) to counteract cell volume changes that may be associated with neuronal activities or …