Liver cirrhosis is the final pathological result of various chronic liver diseases, and fibrosis is
the precursor of cirrhosis. Many types of cells, cytokines and miRNAs are involved in the …

Adipokines are polypeptides secreted in the adipose tissue in a regulated manner. While
some of these molecules are expressed only by adipocytes, resident and infiltrating …

Metabolic processes utilize a variety of differing and contrasting biochemical routes to
enable synthesis of degradation and activation or deactivation of substances; in addition …

Leptin is a an adipocyte-secreted hormone that regulates weight centrally. However, the
leptin receptor is expressed not only in the central nervous system, but also in peripheral …

Nonalcoholic fatty liver disease (NAFLD) has, although it is a very common disorder, only
relatively recently gained broader interest among physicians and scientists. Fatty liver has …

The incidence of obesity has dramatically increased in recent years. Consequently, obesity
and associated disorders such as nonalcoholic fatty liver disease (NAFLD) constitute a …

Non-alcoholic fatty liver disease (NAFLD), the most common liver disorder in the Western
world, is a clinico-histopathological entity in which excessive triglyceride accumulation in the …

Given the pandemic spread of the hepatitis C virus (HCV) infection and the metabolic
syndrome (MS), the burden of their interaction is a major public health issue, bound to …

Leptin and adiponectin, the main metabolic products of adipose tissue, have been
implicated in a wide spectrum of human diseases. Given the frequent presence of hepatic …

Leptin is recognized as a profibrogenic hormone in the liver, but the mechanisms involved
have not been clarified. The tissue inhibitor of metalloproteinase (TIMP)-1, which acts …