It has been found that the majority of disease-associated genetic variants identified by
genome-wide association studies are located outside of protein-coding regions, where they …

PTHrP was identified as a cause of hypercalcemia in cancer patients 25 yr ago. In the
intervening years, we have learned that PTHrP and PTH are encoded by related genes that …

Although parathyroid hormone-related protein (PTHrP) was discovered as a cancer-derived
hormone, it has been revealed as an important paracrine/autocrine regulator in many …

Cardiovascular disease is the most common cause of death worldwide, and hypertension is
the major risk factor. Mendelian hypertension elucidates mechanisms of blood pressure …

Background: High blood pressure is the primary risk factor for cardiovascular death
worldwide. Autosomal dominant hypertension with brachydactyly clinically resembles salt …

Translocations are chromosomal rearrangements that are frequently associated with a
variety of disease states and developmental disorders. We identified 2 families with …

Context: Acrodysostosis is a rare skeletal dysplasia that is associated with multiple
resistance to G protein-coupled receptor (GPCR) signaling hormones in a subset of patients …

Parathyroid hormone (PTH)-related protein (PTHrP), regulated by Indian hedgehog and
acting through the PTH/PTHrP receptor (PPR), is crucial for normal cartilage development …

Objective To examine the expression of ADAMTS-7 during the progression of osteoarthritis
(OA), defining its role in the pathogenesis of OA, and elucidating the molecular events …

Hypertension with brachydactyly (HTNB) represents an autosomal dominant form of
hypertension. It is a rare syndrome, in which the blood pressure can rise by more than 50 …