The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …

Telomerase elongates telomeres and is crucial for maintaining genomic stability. While stem
cells and cancer cells display high telomerase activity, normal somatic cells lack telomerase …

The review describes the role of telomeres and telomerase in tumor progression, as well as
various mechanisms of the activation of telomerase reverse transcriptase (TERT) expression …

Human silencers have been shown to exist and regulate developmental gene expression.
However, the functional importance of human silencers needs to be elucidated such as the …

Activating mutations in the Telomerase Reverse Transcriptase (TERT) promoter are the
single most common non-coding mutation in cancer and enable limitless cell division …

Active telomerase is essential for stem cells and most cancers to maintain telomeres. The
enzymatic activity of telomerase is related but not equivalent to the expression of TERT, the …