Tumor cells evolve in a complex and heterogeneous environment composed of different cell
types and an extracellular matrix. Current 2D culture methods are very limited in their ability …

Mitochondria supply cells with energy in the form of ATP, guide apoptosis, and contribute to
calcium buffering and reactive oxygen species production. To support these diverse …

Energy metabolism is a key aspect of cardiomyocyte biology. Human induced pluripotent
stem cell-derived cardiomyocytes (hiPSC-CMs) are a promising tool for biomedical …

Ageing is a multifactorial biological process leading to a progressive decline of physiological
functions. The process of ageing includes numerous changes in the cells and the …

Induced pluripotent stem cells (iPSCs) have the ability to differentiate into cardiomyocytes
(CMs). They are not only widely used in cardiac pharmacology screening, human heart …

Reprograming of proline metabolism is critical for tumor growth. Here we show that PINCH-1
is highly expressed in lung adenocarcinoma and promotes proline synthesis through …

Although the extracellular matrix (ECM) plays essential roles in heart tissue engineering, the
optimal ECM components for heart tissue organization have not previously been elucidated …

Aim: To discuss the progress of extracellular matrix (ECM) characteristics, mitochondrial
homeostasis, and their potential crosstalk in the pathogenesis of sarcopenia, a geriatric …

Cardiac tissue development and pathology have been shown to depend sensitively on
microenvironmental mechanical factors, such as extracellular matrix stiffness, in both in vivo …

Relevant, predictive normal, or disease model systems are of vital importance for drug
development. The difference between nonhuman models and humans could contribute to …