Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …

The spread of modern humans across the globe has led to genetic adaptations to diverse
local environments. Recent developments in genomic technologies, statistical analyses, and …

Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …

Abstract In European and many African, Middle Eastern and southern Asian populations,
lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over …

Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …

Humans possess an extraordinary capacity for cultural production, from the arts and
language to science and technology. How did the human mind—and the uniquely human …

Searches for the genetic underpinnings of uniquely human traits have focused on human-
specific divergence in conserved genomic regions, which reflects adaptive modifications of …

The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …

African Americans have higher rates of kidney disease than European Americans. Here, we
show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and …

Despite great progress in identifying genetic variants that influence human disease, most
inherited risk remains unexplained. A more complete understanding requires genome-wide …