Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications

IA Khalil, B Saleh, DM Ibrahim, C Jumelle, A Yung… - Biomaterials …, 2020 - pubs.rsc.org
The management of corneal infections often requires complex therapeutic regimens
involving the prolonged and high-frequency application of antibiotics that provide many …

Pharmaceutical salts of fenbendazole with organic counterions: structural analysis and solubility performance

AO Surov, NA Vasilev, MV Vener… - Crystal Growth & …, 2021 - ACS Publications
In this work, three new pharmaceutical salts of fenbendazole (FNB), a benzimidazole-based
anthelmintic drug, with sulfonic acids have been obtained and thoroughly investigated by …

Novel hydrate and anhydrate cocrystals/salts of norfloxacin and their physicochemical properties

A Gunnam, AK Nangia - Crystal Growth & Design, 2023 - ACS Publications
The low solubility and low permeability of Biopharmaceutics Classification System BCS
class IV antibiotic drug norfloxacin (NORF) were studied for improvement of …

Antimicrobial activities of highly bioavailable organic salts and ionic liquids from fluoroquinolones

MM Santos, C Alves, J Silva, C Florindo, A Costa… - Pharmaceutics, 2020 - mdpi.com
As the development of novel antibiotics has been at a halt for several decades, chemically
enhancing existing drugs is a very promising approach to drug development. Herein, we …

Multicomponent Crystals of Amitriptyline as Potential Controlled-Release Systems: Synthesis, Crystal Packing Analysis, and Dissolution Study

AP Voronin, AG Ramazanova, AO Surov… - Crystal Growth & …, 2023 - ACS Publications
In the present work, for the first time, a crystal engineering approach was systematically
applied to produce novel crystalline forms of the tricyclic antidepressant amitriptyline (AMT) …

Melting points of one-and two-component molecular crystals as effective characteristics for rational design of pharmaceutical systems

G Perlovich - Acta Crystallographica Section B: Structural Science …, 2020 - journals.iucr.org
Based on the review of the literature results the database of the fusion temperatures of two-
component molecular crystals (1947 co-crystals) and individual components thereof was …

Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study

AC de Almeida, C Torquetti, PO Ferreira… - Thermochimica …, 2020 - Elsevier
This article describes the synthesis and characterization of new cocrystals of ciprofloxacin
with nicotinic and isonicotinic acids as coformers. The cocrystals were obtained by a …

Confined effect of water solution of ciprofloxacin in carbon nanotubes studied by Raman and Fourier Transform Infrared Spectroscopy methods

N Przybylska, M Śliwińska-Bartkowiak… - Journal of Molecular …, 2021 - Elsevier
In this work we refer the properties of water solution of ciprofloxacin confined in single wall
carbon nanotubes. Ciprofloxacin is well-known antibiotic applied against Gram-positive and …

Solid forms of ciprofloxacin salicylate: polymorphism, formation pathways, and thermodynamic stability

AO Surov, NA Vasilev, AV Churakov, J Stroh… - Crystal Growth & …, 2019 - ACS Publications
The crystallization of ciprofloxacin—an antibacterial fluoroquinolone compound—with
salicylic acid resulted in the isolation of five distinct solid forms of the drug, namely, an …

First Cocrystallization of Gatifloxacin with Nutraceuticals Displays the Ameliorated In Vitro/Vivo Biopharmaceutical Property and Increased Antibacterial Activity

CC Xie, ZL Zhao, MY Huang, Z Li… - Crystal Growth & …, 2023 - ACS Publications
A drug-nutrient cocrystallization strategy has been established to allow full play to the
preponderances of phenolic acid nutrients ferulic acid (FLA) and vanillic acid (VLA) in …