MODOMICS: a database of RNA modifications and related information. 2023 update

A Cappannini, A Ray, E Purta, S Mukherjee… - Nucleic Acids …, 2024 - academic.oup.com
The MODOMICS database was updated with recent data and now includes new data types
related to RNA modifications. Changes to the database include an expanded modification …

Exploring antibiotic resistance with chemical tools

WA Velema - Chemical Communications, 2023 - pubs.rsc.org
Antibiotic resistance is an enormous problem that is accountable for over a million deaths
annually, with numbers expected to significantly increase over the coming decades …

2′-OH as a universal handle for studying intracellular RNAs

L Xiao, L Fang, ET Kool - Cell Chemical Biology, 2024 - cell.com
RNA plays pivotal roles in most cellular processes, serving as both the traditional carrier of
genetic information and as a key regulator of cellular functions. The advent of chemical …

[HTML][HTML] Structural brain preservation: a potential bridge to future medical technologies

AT McKenzie, A Zeleznikow-Johnston… - Frontiers in medical …, 2024 - frontiersin.org
When faced with the prospect of death, some people would prefer a form of long-term
preservation that may allow them to be restored to healthy life in the future, if technology …

G-Clamp Heterocycle Modification Containing Interstrand Photo-Cross-Linker to Capture Intracellular MicroRNA Targets

W Shen, Y Hou, Y Yi, F Li, C He… - Journal of the American …, 2024 - ACS Publications
MicroRNAs (miRNAs) play indispensable roles in post-transcriptional gene regulation. The
identification of target mRNAs is essential for dissecting the recognition basis, dynamics …

Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization

MR Chao, YJ Chang, MS Cooke, CW Hu - TrAC Trends in Analytical …, 2024 - Elsevier
Adductomics, an emerging field within the'omics sciences, focuses on the formation and
prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous …

[HTML][HTML] Selective activation of prodrugs in breast cancer using metabolic glycoengineering and the tetrazine ligation bioorthogonal reaction

MMA Mitry, ML Dallas, SY Boateng, F Greco… - Bioorganic …, 2024 - Elsevier
Increasing the selectivity of chemotherapies by converting them into prodrugs that can be
activated at the tumour site decreases their side effects and allows discrimination between …

Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts

BA Khalifah, SA Alghamdi, AH Alhasan - Frontiers in Bioengineering …, 2023 - frontiersin.org
Human transcriptome can undergo RNA mis-splicing due to spliceopathies contributing to
the increasing number of genetic diseases including muscular dystrophy (MD), Alzheimer …

[HTML][HTML] Biostasis: A roadmap for research in preservation and potential revival of humans

AT McKenzie, B Wowk, A Arkhipov, B Wróbel, N Cheng… - Brain Sciences, 2024 - mdpi.com
Human biostasis, the preservation of a human when all other contemporary options for
extension of quality life are exhausted, offers the speculative potential for survival via …

Chemical crosslinking and ligation methods for in vivo analysis of RNA structures and interactions

WH Lee, K Li, Z Lu - Methods in enzymology, 2023 - Elsevier
RNA structures and interactions in living cells drive a variety of biological processes and
play critical roles in physiology and disease states. However, studies of RNA structures and …