The making of hypervirulent Klebsiella pneumoniae

P Dai, D Hu - Journal of Clinical Laboratory Analysis, 2022 - Wiley Online Library
Klebsiella pneumoniae is a notorious bacterium in clinical practice. Virulence, carbapenem‐
resistance and their convergence among K. pneumoniae are extensively discussed in this …

Evolution and ecology of CRISPR

ER Westra, AJ Dowling, JM Broniewski… - Annual Review of …, 2016 - annualreviews.org
CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-
associated) systems are prokaryotic adaptive immune systems that provide protection …

The CRISPR spacer space is dominated by sequences from species-specific mobilomes

SA Shmakov, V Sitnik, KS Makarova, YI Wolf… - MBio, 2017 - Am Soc Microbiol
Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein
(CRISPR-Cas) systems store the memory of past encounters with foreign DNA in unique …

[HTML][HTML] CRISPR–Cas: complex functional networks and multiple roles beyond adaptive immunity

G Faure, KS Makarova, EV Koonin - Journal of molecular biology, 2019 - Elsevier
CRISPR–Cas is a prokaryotic adaptive immune system that functions by incorporating
fragments of foreign DNA into CRISPR arrays. The arrays containing spacers derived from …

Antiviral goes viral: harnessing CRISPR/Cas9 to combat viruses in humans

JA Soppe, RJ Lebbink - Trends in microbiology, 2017 - cell.com
The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated (Cas) systems are RNA-guided sequence-specific prokaryotic antiviral immune …

Food spoilage-associated Leuconostoc, Lactococcus, and Lactobacillus species display different survival strategies in response to competition

M Andreevskaya, E Jääskeläinen… - Applied and …, 2018 - Am Soc Microbiol
Psychrotrophic lactic acid bacteria (LAB) are the prevailing spoilage organisms in packaged
cold-stored meat products. Species composition and metabolic activities of such LAB …

Bacterial autoimmunity due to a restriction-modification system

M Pleška, L Qian, R Okura, T Bergmiller, Y Wakamoto… - Current Biology, 2016 - cell.com
Restriction-modification (RM) systems represent a minimal and ubiquitous biological system
of self/non-self discrimination in prokaryotes [1], which protects hosts from exogenous DNA …

Do fungi have an innate immune response? An NLR-based comparison to plant and animal immune systems

J Uehling, A Deveau, M Paoletti - PLoS pathogens, 2017 - journals.plos.org
Survival and evolutionary success of living organisms directly depend on the ability to
respond appropriately to their biotic environments. Plants and animals have developed …

The conceptual foundations of innate immunity: Taking stock 30 years later

T Pradeu, BPHJ Thomma, SE Girardin, B Lemaitre - Immunity, 2024 - cell.com
While largely neglected over decades during which adaptive immunity captured most of the
attention, innate immune mechanisms have now become central to our understanding of …

Phage therapy: a new horizon in the antibacterial treatment of oral pathogens

M Shlezinger, L Khalifa, Y Houri-Haddad… - Current topics in …, 2017 - ingentaconnect.com
Dental diseases are perhaps the most prevalent infection-related diseases in humans.
Biofilm is involved in almost every infectious disease compromising oral health, notably …