The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is
evident by the fact that heterozygous mutations in the major structural proteins or kinases …

Objective This study aims to evaluate the diagnostic value of D-dimer for acute aortic
dissection (AAD) by the method of meta-analysis. Methods PubMed, Cochrane Library, Web …

Recent studies reported some long noncoding RNAs (lncRNAs)–mediated vascular smooth
muscle cells (VSMCs) phenotypic switch, which was a common pathophysiological process …

Enhancer of zeste homolog 2 (EZH2), a methyltransferase that di-and tri-methylates lysine-
27 of histone H3, largely functions as a transcriptional repressor, and plays a critical role in …

Myocardin is a muscle-restricted transcriptional coactivator that activates a serum response
factor (SRF)-dependent gene program required for cardiogenesis and embryonic survival …

Endometrial cancer is one of the most frequently diagnosed gynecological cancers
worldwide, and its prevalence has increased by more than 50% over the last two decades …

Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the
population but its aetiology, including suspected genetic predisposition, is poorly …

Genetic studies have yielded important genes contributing to both early-onset and adult-
onset forms of glaucoma. The proteins encoded by the current collection of glaucoma genes …

TMCO1 (transmembrane and coiled-coil domains 1) is an endoplasmic reticulum (ER)
transmembrane protein that actively prevents Ca2+ stores from overfilling. To characterize …

Pathogenic variants in myosin heavy chain (Myh11) cause familial thoracic aortic aneurysms
and dissections (FTAAD). However, the underlying pathological mechanisms remain …