Although anti− cancer immuno− based combinatorial therapeutic approaches have shown
promising results, efficient tumour eradication demands further intensification of anti− tumour …

Expression of the αvβ6 integrin is upregulated in several solid tumors. In contrast,
physiologic expression of this epithelial-specific integrin is restricted to development and …

Despite its role in cancer surveillance, adoptive immunotherapy using γδ T cells has
achieved limited efficacy. To enhance trafficking to bone marrow, circulating Vγ9Vδ2 T cells …

Retroviral (RV) expression of genes of interest (GOIs) is an invaluable tool and has formed
the foundation of cellular engineering for adoptive cell therapy in cancer and other diseases …

Cellular therapies are engineered using foreign and synthetic protein sequences, such as
chimeric antigen receptors (CARs). The frequently observed humoral responses to CAR T …

Radiotherapy is a cancer treatment utilising high doses of ionizing radiation to destroy
cancer cells. Our team has pioneered neutron activation of 152 Sm, filled and sealed into …

Cancer immunotherapy using chimeric antigen receptor (CAR) T-cells has shown
exceptional promise in the treatment of patients with refractory B-cell malignancy. In this …

Objectives: One in two patients with stage 4 melanoma will not survive their first year after
diagnosis. Although recent treatment advances have improved survival, there is an unmet …

There is provided a kind of method for expanding gamma delta T cell mass, wherein in the
culture medium comprising transforming growth factor β (TGF β), the PMBC (PBMC) of the …

Second generation chimeric antigen receptors (CARs) containing a CD28 or 4-1BB
costimulatory endodomain have shown remarkable efficacy against hematological …