Inflammation is a part of the complex biological response of inflammatory cells to harmful
stimuli, such as pathogens, irritants, or damaged cells. This inflammation has been linked to …

Measurements of bone markers (BMs) in peripheral blood or urine are a pivotal part of bone
research within modern clinical medicine. In recent years the use of BMs increased …

Background Treatment options for metastatic castration-resistant prostate cancer (mCRPC)
have expanded in recent years and include cytotoxic agents (eg, docetaxel and …

Prostate cancer is the most commonly diagnosed non-cutaneous neoplasm in men in the
United States and the second leading cause of cancer mortality. One in 7 men will be …

The exact role of biochemical markers of bone turnover in the management of metabolic
bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone …

Skeletal metastases of unknown primary (SMUP) represent a clinical challenge in dealing
with patients diagnosed with bone metastases. Management of these patients has improved …

Background Bone formation marker procollagen I N-terminal peptide (PINP) and resorption
marker C-terminal telopeptide of type I collagen (β-CTX) are useful biomarkers for …

Bone metastases are characterized by increased osteoblastic and/or osteolytic processes
depending on the tumor type. The altogether destructive effect of metastasis formation …

Purpose Whether N-telopeptide of type I collagen (NTx) can be applied for diagnosis and
prognostic prediction of bone metastasis in human cancers is still conflicting. This study …

Background Prior studies suggest that elevated markers of bone turnover are prognostic for
poor survival in castration-resistant prostate cancer (CRPC). The predictive role of these …