Brown adipose tissue (BAT) is increasingly recognized as the major therapeutic target to
promote energy expenditure and ameliorate diverse metabolic complications. There is a …

Metformin (MF), a first-line drug to treat type 2 diabetes mellitus (T2DM), alone and in
combination with other drugs, restores the ovarian function in women with polycystic ovary …

Retinal ischemia/reperfusion (I/R) injury is a common pathological process responsible for
cellular damage in glaucoma, diabetic retinopathy and hypertensive retinopathy. Metformin …

Metformin (dimethyl‐biguanide) can claim its origins in the use of Galega officinalis as a
plant treatment for symptoms ascribed to diabetes. Since the first clinical use of metformin as …

Metformin, a well‐known AMPK agonist, has been widely used as the first‐line drug for
treating type 2 diabetes. There had been a significant concern regarding the use of …

AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status
in eukaryotic cells. It plays a key role in regulating cellular energy homeostasis and multiple …

Metformin is a plant-based drug belonging to the class of biguanides and is known to treat
type-2 diabetes mellitus (T2DM). The drug, combined with controlling blood glucose levels …

Skeletal muscle is one of the largest organs in the body and the largest protein repository.
Mitochondria are the main energy-producing organelles in cells and play an important role …

Abstract Type 2 Diabetes Mellitus (T2DM) is characterized by hepatic insulin resistance,
which results in increased glucose production and reduced glycogen storage in the liver …

Hematologic malignancies (HMs) mainly include acute and chronic leukemia, lymphoma,
myeloma and other heterogeneous tumors that seriously threaten human life and health …