Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …

The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

Some viral outbreaks have plagued the world since antiquity, including the most recent
COVID-19 pandemic. The continuous spread and emergence of new viral diseases have …

Apoptosis deficiency is one of the most important features observed in neoplastic diseases.
The Bcl-2 family is composed of a subset of proteins that act as decisive apoptosis …

Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and
inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells …

The aim of this study was to synthesize chalcone-polyamine conjugates in order to enhance
bioavailability and selectivity of chalcone core towards cancer cells, using polyamine-based …

Cancer continues to be a global health challenge, thereby necessitating the evolution of
innovative therapeutic strategies. The synthesis of chalcone derivatives has garnered …

Chalcones are members of the flavonoid family and act as intermediates in the biosynthesis
of flavonoids, which are widespread in plants. Meanwhile, chalcones are important …

Background: Although triple-negative breast cancer (TNBC) accounts for only 15% of breast
cancer cases, it is associated with a high relapse rate and poor outcome after standard …