The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly
with the aging of the population. Numerous epidemiological data suggest that there is a …

Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular
processes in neurons, the dysregulation of which compromises normal brain function. The …

The dismal success rate of clinical trials for Alzheimer's disease (AD) motivates us to
develop model systems of AD pathology that have higher predictive validity. The advent of …

Accumulations of insoluble deposits of amyloid β-peptide are major pathological hallmarks
of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from …

Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have
been the focus of numerous investigations over the past two decades. APP is the precursor …

Amyloid precursor protein (APP) is a key player in Alzheimer's disease (AD). The Aβ
fragments of APP are the major constituent of AD-associated amyloid plaques, and …

It has been over 20 years since JUN amino-terminal kinases (JNKs) were identified as
protein kinases that are strongly activated by cellular stress and that have a key role in …

The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to
the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form …

With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …

Abstract Glycogen synthase kinase-3 (GSK3) was initially identified more than two decades
ago as an enzyme involved in the control of glycogen metabolism. In recent years it has …