Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue
repair by controlling many cellular processes including stem cell self-renewal, lineage …

In 46, XY men, testis is determined by a genetic network (s) that both promotes testis
formation and represses ovarian development. Disruption of this process results in a lack of …

Polycomb group (PcG) proteins maintain the repressed state of lineage-inappropriate genes
and are therefore essential for embryonic development and adult tissue homeostasis. One …

Recent studies have revealed a surprising diversity of sex chromosomes in vertebrates.
However, the detailed mechanism of their turnover is still elusive. To understand this …

Mammalian sexual development commences when fetal bipotential progenitor cells adopt
male Sertoli (in XY) or female granulosa (in XX) gonadal cell fates. Differentiation of these …

Formation of either an ovary or a testis during human embryonic life is one of the most
important sex-specific events leading to the emergence of secondary sexual characteristics …

Disorders (or differences) of sex development (DSD) are a heterogeneous group of
congenital conditions with variations in chromosomal, gonadal, or anatomical sex. Impaired …

Most vertebrates develop distinct females and males, where sex is determined by repeatedly
evolved environmental or genetic triggers. Undifferentiated sex chromosomes and large …

The cell division cycle-associated protein (CDCA) family is important in regulating cell
division. High CDCA expression is significantly linked to tumor development. This review …