Abstract Studies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the
African trypanosome, Trypanosoma brucei, have yielded a remarkable range of novel and …

African trypanosomes are unicellular, eukaryotic parasites that live extracellularly in a wide
range of mammals, including humans. They have a surface coat, composed of variant …

Infectivity of Trypanosoma brucei rhodesiense to humans is due to its resistance to a lytic
factor present in human serum. In the ETat 1 strain this character was associated with …

Intergenic regions of polycistronic pre-mRNAs of trypanosomatid protozoans are the sites of
two processing reactions: polyadenylation of the upstream gene and trans-splicing of the …

Variant surface glycoprotein (VSG) coats bloodstream form Trypanosoma brucei parasites,
and monoallelic VSG expression underpins the antigenic variation necessary for …

Trypanosomes are protozoan agents of major parasitic diseases such as Chagas' disease in
South America and sleeping sickness of humans and nagana disease of cattle in Africa …

Results A 100 Nucleotide Fragment of the SL RNA Is Associated with High Molecular Weight
RNA Throughout this manuscript we will consider the 135 nucleotide SL RNA as having two …

Pathogenic microbes have evolved highly sophisticated mechanisms for colonizing host
tissues and evading or deflecting assault by the immune response. The ability of these …

We have used inactivation of transcription by UV irradiation to map transcription units In
trypanosomes. The relative inactivation rate of the transcription of mini-exon, 5S, and rRNA …

Antigenic variation is an immune evasion strategy used by African trypanosomes, in which
the parasites periodically switch the expression of VSG genes that encode their protective …