The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …

Plants encounter a myriad of microorganisms, particularly at the root–soil interface, that can
invade with detrimental or beneficial outcomes. Prevalent beneficial associations between …

Innate immune cells can develop long-term memory after stimulation by microbial products
during infections or vaccinations. Here, we report that metabolic signals can induce trained …

Abstract Background Familial Mediterranean fever, mevalonate kinase deficiency (also
known as the hyperimmunoglobulinemia D syndrome), and the tumor necrosis factor …

Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …

A cell is delimited by numerous borders that define specific organelles. The walls of some
organelles are particularly robust, such as in mitochondria or endoplasmic reticulum, but …

Macrophages are first responders for the immune system. In this role, they have both effector
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …

Autoinflammatory diseases were first recognized nearly 20 years ago as distinct clinical and
immunological entities caused by dysregulation in the innate immune system. Since then …

Cholesterol is a multifaceted metabolite that is known to modulate processes in cancer,
atherosclerosis, and autoimmunity. A common denominator between these diseases …

The innate immune system uses a distinct set of germline-encoded pattern recognition
receptors (PRRs) to initiate downstream inflammatory cascades. This recognition system is …