Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms

PK Ajikumar, K Tyo, S Carlsen, O Mucha… - Molecular …, 2008 - ACS Publications
Terpenoids represent a diverse class of molecules that provide a wealth of opportunities to
address many human health and societal issues. The expansive array of structures and …

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

GD Brown - Molecules, 2010 - mdpi.com
The Chinese medicinal plant Artemisia annua L.(Qinghao) is the only known source of the
sesquiterpene artemisinin (Qinghaosu), which is used in the treatment of malaria …

Engineering yeast for the production of plant terpenoids using synthetic biology approaches

JA Bureau, ME Oliva, Y Dong, C Ignea - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in
synthesizing these complex structures have stimulated the production of terpenoid …

Metabolic engineering of microorganisms for the synthesis of plant natural products

J Marienhagen, M Bott - Journal of biotechnology, 2013 - Elsevier
Of more than 200,000 plant natural products known to date, many demonstrate important
pharmacological activities or are of biotechnological significance. However, isolation from …

Synthetic biology: promises and challenges

L Serrano - Molecular systems biology, 2007 - embopress.org
Life is evolving fast (at least in the first world) and the latest technological gadget becomes
outdated even before we have learnt how to use it. In this respect, science is no exception …

Metabolic engineering for plant natural product biosynthesis in microbes

JA Chemler, MAG Koffas - Current opinion in biotechnology, 2008 - Elsevier
Plant natural products (NPs) not only serve many functions in an organism's survivability but
also demonstrate important pharmacological activities. Isolation of NPs from native sources …

Medicinally important secondary metabolites in recombinant microorganisms or plants: progress in alkaloid biosynthesis

H Schäfer, M Wink - Biotechnology Journal: Healthcare …, 2009 - Wiley Online Library
Plants produce a high diversity of natural products or secondary metabolites which are
important for the communication of plants with other organisms. A prominent function is the …

Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering

MA Asadollahi, J Maury, KR Patil, M Schalk, A Clark… - Metabolic …, 2009 - Elsevier
A genome-scale metabolic model was used to identify new target genes for enhanced
biosynthesis of sesquiterpenes in the yeast Saccharomyces cerevisiae. The effect of gene …

Endophytes: exploiting biodiversity for the improvement of natural product-based drug discovery

A Staniek, HJ Woerdenbag… - Journal of plant interactions, 2008 - Taylor & Francis
Endophytes, microorganisms that colonize internal tissues of all plant species, create a huge
biodiversity with yet unknown novel natural products, presumed to push forward the frontiers …

Metabolic engineering of microorganisms for the production of natural compounds

SY Park, D Yang, SH Ha, SY Lee - Advanced Biosystems, 2018 - Wiley Online Library
Natural products have been attracting much interest around the world for their diverse
applications, especially in drug and food industries. Plants have been a major source of …