Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic
wounds, and macrophage malfunction is considered as a major contributor thereof. In this …

Despite the great progress in translational research concerning skin wound healing in the
last few decades, no animal model fully predicts all clinical outcomes. The mouse is the most …

Healing skin wounds with anatomic and functional integrity, especially under chronic
pathological conditions, remain an enormous challenge. Due to their outstanding …

Introduction The secretion of trophic factors by mesenchymal stromal cells has gained
increased interest given the benefits it may bring to the treatment of a variety of traumatic …

Significance: With an aging population leading to an increase in diabetes and associated
cutaneous wounds, there is a pressing clinical need to improve wound-healing therapies …

Background Chronic nonhealing wounds represent one of the most common complications
of diabetes and require advanced treatment strategies. Increasing evidence supports the …

Radioactive dermatitis is caused by the exposure of skin and mucous membranes to
radiation fields. The pathogenesis of radioactive dermatitis is complex and difficult to cure …

Wound healing is a major problem in diabetic patients, and current treatments have been
confronted with limited success. The present study examined the benefit of Wharton's jelly …

The skin is the largest organ of the human body, and its dysfunction is related to many
diseases. There is a need to find new potential effective therapies for some skin conditions …

Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent a promising
young-state stem cell source for cell-based therapy. hUCMSC transplantation into the …