[HTML][HTML] A importância das cumarinas para a química medicinal eo desenvolvimento de compostos bioativos nos últimos anos

DP Franco, TM Pereira, F Vitorio, NF Nadur… - Química …, 2021 - SciELO Brasil
Coumarins are natural products characterized as 2H-chromen-2-one, according to IUPAC
nomenclature, largely distributed in plants, as well as, in species of fungi and bacteria …

[图书][B] Chemistry and application of H-phosphonates

KD Troev - 2006 - books.google.com
Chemistry and Application of H-Phosphonates is an excellent source for those planning the
synthesis of new phosphorus-containing compounds and in particular derivatives containing …

Sensitive fluorescent biosensor based on a europium-based metal-organic framework for protein kinase activity analysis

Z Liu, J Bai, C Liang, Y Wang, H Nie, X Liu… - Biosensors and …, 2022 - Elsevier
Protein kinases play crucial regulatory roles in the physiological activities in the human
body. Understanding protein kinase activity and its inhibition is essential for the …

The Discovery of Protheolysis Targeting Chimeras (PROTACs), Evolution, Design and Perspectives in Modulating Inflammatory Diseases

L Caruso, TM Pereira, AE Kümmerle - Journal of the Brazilian …, 2024 - SciELO Brasil
Currently, most drugs have their mode of action based on occupation-oriented
pharmacology (proteins modulation through temporary inhibition by association and …

Semisynthesis and Cytotoxic Activities of Novel Oxime Ester Derivatives of the Diterpene Stemodin

JAC Oliveira, CJ Alves Filho, AMA Lima… - Journal of the Brazilian …, 2024 - SciELO Brasil
Stemodin (1) is a diterpene produced by Stemodia maritima L.(Scrophulariaceae) and
shows antiviral and tumor cell proliferation inhibitory activities. Chemical modifications of 1 …

Synthesis and properties of substituted oxo-and thioxohexahydropyrimidine-5-carboxylic acids

ES Makarova, MV Kabanova, SI Filimonov… - Russian Chemical …, 2022 - Springer
The regularities of the lactone ring opening in hexahydro-2 H-chromeno [4, 3-d] pyrim-idine-
2, 5-diones and thioxohexahydro-5 H-chromeno [4, 3-d] pyrimidines with bases to form the …

Double decarboxylative route to 3-substituted pyrrolidines: Reaction of monoalkyl malonates and related carboxylic acids with sarcosine and formaldehyde

EM Buev, AA Smorodina, VS Moshkin… - Tetrahedron …, 2020 - Elsevier
Three-component reactions of monoalkyl malonates, cyanoacetic acids or 2-ketocarboxylic
acids, N-methylglycine, and formaldehyde were developed to rapidly access 3-substituted …

Synthesis of New (Arylsulfanyl) maleimide Derivatives

AA Panov, AY Simonov, AM Korolev - Russian Journal of Organic …, 2019 - Springer
Abstract Previously unknown 2-(arylsulfanyl)-3-hydroxymaleimide and 2-(arylsulfanyl)-3-
chloromaleimide derivatives have been synthesized, and several synthetic approaches to 2 …

PREPARATION OF COBALT HYDROXIDE FILM MODIFIED ELECTRODE AND ITS ANALYTICAL APPLICATION

F Yueqin, F Lifang, M Shuangming, G Yong… - Журнал …, 2012 - elibrary.ru
Cobalt hydroxide film modified electrode was prepared by depositing cobalt hydroxide on
glassy carbon electrode (GCE) surface in an alkaline aqueous solution and then …