The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …

A major resistance mechanism in Gram-negative bacteria is the production of β-lactamase
enzymes. Originally recognized for their ability to hydrolyze penicillins, emergent β …

In this review, the history of boron's early use in drugs, and the history of the use of boron
functional groups in medicinal chemistry applications are discussed. This includes …

The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

As shifts in the epidemiology of β-lactamase-mediated resistance continue, carbapenem-
resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa …

Boron-containing molecules have been extensively used for the purposes of chemical
sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it …

The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in
clinical development. We report that VNRX-5133 inhibits serine-β-lactamases (SBLs) and …