Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that
recognize short peptide antigens presented on major histocompatibility complex (MHC) …

This article addresses the clinical presentation, diagnosis, pathophysiology and
management of narcolepsy type 1 and 2, with a focus on recent findings. A low level of …

SARS-CoV2 infection is responsible for a complex clinical syndrome, named Coronavirus
Disease 2019 (COVID-19), whose main consequences are severe pneumonia and acute …

The orexin system comprises two G protein-coupled receptors, orexin 1 receptor (OX1R)
and orexin 2 receptor (OX2R), along with two endogenous agonists cleaved from a common …

Purpose Narcolepsy type-1 (NT1) is a rare chronic neurological sleep disorder with
excessive daytime sleepiness (EDS) as usual first and cataplexy as pathognomonic …

Abstract Narcolepsy type 1 (NT1) and type 2 (NT2), also known as narcolepsy with and
without cataplexy, are sleep disorders that benefited from major scientific advances over the …

Narcolepsy is a rare chronic neurological disorder characterized by an irresistible excessive
daytime sleepiness and cataplexy. The disease is considered to be the result of the selective …

Neurological autoimmune diseases are characterized by an inappropriate immune
response that by mistake targets the nervous system. As a result, patients experiment a …