The dynamic lung microbiome in health and disease

JG Natalini, S Singh, LN Segal - Nature Reviews Microbiology, 2023 - nature.com
New methods and technologies within the field of lung biology are beginning to shed new
light into the microbial world of the respiratory tract. Long considered to be a sterile …

[PDF][PDF] The role of lung and gut microbiota in the pathology of asthma

W Barcik, RCT Boutin, M Sokolowska, BB Finlay - Immunity, 2020 - cell.com
Asthma is a common chronic respiratory disease affecting more than 300 million people
worldwide. Clinical features of asthma and its immunological and molecular etiology vary …

The microbiome of the upper respiratory tract in health and disease

C Kumpitsch, K Koskinen, V Schöpf… - BMC biology, 2019 - Springer
The human upper respiratory tract (URT) offers a variety of niches for microbial colonization.
Local microbial communities are shaped by the different characteristics of the specific …

Primary prevention of asthma: from risk and protective factors to targeted strategies for prevention

E von Mutius, HH Smits - The Lancet, 2020 - thelancet.com
Asthma is a complex disease that often starts in childhood. Genomic and environmental
factors as well as aberrant immune maturation early in life can contribute to the onset of …

[HTML][HTML] The microbiota of the respiratory tract: gatekeeper to respiratory health

WH Man, WAA de Steenhuijsen Piters… - Nature Reviews …, 2017 - nature.com
The respiratory tract is a complex organ system that is responsible for the exchange of
oxygen and carbon dioxide. The human respiratory tract spans from the nostrils to the lung …

Dysbiosis of the gut and lung microbiome has a role in asthma

K Hufnagl, I Pali-Schöll, F Roth-Walter… - Seminars in …, 2020 - Springer
Worldwide 300 million children and adults are affected by asthma. The development of
asthma is influenced by environmental and other exogenous factors synergizing with …

[HTML][HTML] Research progress in atopic march

L Yang, J Fu, Y Zhou - Frontiers in immunology, 2020 - frontiersin.org
The incidence of allergic diseases continues to rise. Cross-sectional and longitudinal
studies have indicated that allergic diseases occur in a time-based order: from atopic …

Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies

DM Patrick, H Sbihi, DLY Dai, A Al Mamun… - The Lancet …, 2020 - thelancet.com
Background Childhood asthma incidence is decreasing in some parts of Europe and North
America. Antibiotic use in infancy has been associated with increased asthma risk. In the …

[HTML][HTML] The healthy human blood microbiome: fact or fiction?

DJ Castillo, RF Rifkin, DA Cowan… - Frontiers in cellular and …, 2019 - frontiersin.org
The blood that flows perpetually through our veins and arteries performs numerous functions
essential to our survival. Besides distributing oxygen, this vast circulatory system facilitates …

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

A Langdon, N Crook, G Dantas - Genome medicine, 2016 - Springer
The widespread use of antibiotics in the past 80 years has saved millions of human lives,
facilitated technological progress and killed incalculable numbers of microbes, both …