Importance Alzheimer disease (AD) pathology starts with a prolonged phase of β-amyloid
(Aβ) accumulation without symptoms. The duration of this phase differs greatly among …

Alzheimer's disease biomarkers are becoming increasingly important for characterizing the
longitudinal course of disease, predicting the timing of clinical and cognitive symptoms, and …

Background Characterizing cerebrovascular hemodynamics in older adults is important for
identifying disease and understanding normal neurovascular aging. Four-dimensional (4D) …

Background: The major mechanisms of dementia and cognitive impairment are vascular and
neurodegenerative processes. Early diagnosis of cognitive impairment can facilitate timely …

An accurate blood test for Alzheimer's disease that is sensitive to preclinical proteinopathy
and cognitive decline has clear implications for early detection and secondary prevention …

Background and Objectives To determine the relevance of minor neuropsychological deficits
(MNPD) in patients with subjective cognitive decline (SCD) with regard to CSF levels of …

Neurovascular 4D-Flow MRI enables non-invasive evaluation of cerebral hemodynamics
including measures of cerebral blood flow (CBF), vessel pulsatility index (PI), and cerebral …

Objective: The preeminent in vivo cerebrospinal fluid (CSF) biomarkers of Alzheimer's
disease (AD) are amyloid β 1–42 (Aβ42), phosphorylated Tau (p-tau), and total Tau (t-tau) …

Background Detecting impaired naming capacity contributes to the detection of mild
(MildND) and major (MajorND) neurocognitive disorder due to Alzheimer's disease (AD) …

Previous studies suggest associations between self-reported sleep problems and poorer
health, cognition, Alzheimer's disease pathology and dementia-related outcomes. It is …