The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

Binge or chronic alcohol consumption causes neuroinflammation and leads to alcohol use
disorder (AUD). AUD not only affects the central nervous system (CNS) but also leads to …

Neuropeptides are evolutionarily ancient mediators of neuronal signalling in nervous
systems. With recent advances in genomics/transcriptomics, an increasingly wide range of …

Background & Aims Tachykinins are involved in physiological and pathophysiological
mechanisms in the gastrointestinal tract. The major sources of tachykinins in the gut are …

Sensory neurons in the gastrointestinal tract have multifaceted roles in maintaining
homeostasis, detecting danger and initiating protective responses. The gastrointestinal tract …

The gut immune system shares many mediators and receptors with the autonomic nervous
system. Good examples thereof are the parasympathetic (vagal) and sympathetic …

Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease
(PD), are characterized by deposits of amyloid proteins. The homeostasis of metal ions is …

Historically, emesis was considered a simple reflex localized to a putative “vomiting center”
in the brain. However, it quickly became clear that this idea was insufficient, and that emesis …

Serotonin, a central neuromodulator with ancient ties to feeding and metabolism, is a major
driver of body fat loss. However, mechanisms by which central serotonin action leads to fat …

Members of the tachykinin peptide family have been well conserved during evolution and
are mainly expressed in the central nervous system and in the intestine of both vertebrates …