Prenatal infection and schizophrenia: a review of epidemiologic and translational studies

AS Brown, EJ Derkits - American Journal of Psychiatry, 2010 - Am Psychiatric Assoc
An emerging literature from epidemiologic, clinical, and preclinical investigations has
provided evidence that gestational exposure to infection contributes to the etiology of …

Genetics of aggressive behavior: an overview

K Veroude, Y Zhang‐James… - American Journal of …, 2016 - Wiley Online Library
The Research Domain Criteria (RDoC) address three types of aggression: frustrative non‐
reward, defensive aggression and offensive/proactive aggression. This review sought to …

Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer

R Tabares-Seisdedos, JLR Rubenstein - Molecular psychiatry, 2009 - nature.com
Defects in genetic and developmental processes are thought to contribute susceptibility to
autism and schizophrenia. Presumably, owing to etiological complexity identifying …

Mouse behavioral endophenotypes for schizophrenia

LC Amann, MJ Gandal, TB Halene, RS Ehrlichman… - Brain research …, 2010 - Elsevier
An endophenotype is a heritable trait that is generally considered to be more highly,
associated with a gene-based neurological deficit than a disease phenotype itself. Such …

Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors

GM Pitcher, LV Kalia, D Ng, NM Goodfellow, KT Yee… - Nature medicine, 2011 - nature.com
Hypofunction of the N-methyl d-aspartate subtype of glutamate receptor (NMDAR) is
hypothesized to be a mechanism underlying cognitive dysfunction in individuals with …

[HTML][HTML] Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test

V Almeida, R Levin, FF Peres, ST Niigaki… - Progress in Neuro …, 2013 - Elsevier
Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been
reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We …

Losing your inhibition: linking cortical GABAergic interneurons to schizophrenia

M Inan, TJ Petros, SA Anderson - Neurobiology of disease, 2013 - Elsevier
GABAergic interneurons of the cerebral cortex (cINs) play crucial roles in many aspects of
cortical function. The diverse types of cINs are classified into subgroups according to their …

Phenotypic characterization of transgenic mice overexpressing neuregulin-1

T Kato, A Kasai, M Mizuno, L Fengyi, N Shintani… - PloS one, 2010 - journals.plos.org
Background Neuregulin-1 (NRG1) is one of the susceptibility genes for schizophrenia and
implicated in the neurotrophic regulation of GABAergic and dopaminergic neurons …

Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions

RS Ehrlichman, SN Luminais, SL White, ND Rudnick… - Brain research, 2009 - Elsevier
INTRODUCTION: Neuregulin-1 (NRG1) is one of susceptibility genes for schizophrenia and
plays critical roles in glutamatergic, dopaminergic and GABAergic signaling. Using mutant …

Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice

LE Long, R Chesworth, XF Huang, A Wong, A Spiro… - PloS one, 2012 - journals.plos.org
The cannabis constituent cannabidiol (CBD) possesses anxiolytic and antipsychotic
properties. We have previously shown that transmembrane domain neuregulin 1 mutant …