Nitrogen-containing heterocyclic rings are common structural components of marketed
drugs. Among these heterocycles, imidazole/fused imidazole rings are present in a wide …

Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

Glioblastoma (GBM) is the most common aggressive malignant tumor in brain
neuroepithelial tumors and remains incurable. A variety of treatment options are currently …

Glioblastoma multiforme (GBM) is a notably lethal brain tumor associated with high
proliferation rate and therapeutic resistance, while currently effective treatment options are …

Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and
high recurrence rate. The presence of the blood–brain barrier (BBB) prevents diagnostic and …

Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many
solid tumors as ALDHs may regulate cell proliferation and chemoresistance of cancer stem …

The aggressive and recurrent nature of glioblastoma is multifactorial and has been attributed
to its biological heterogeneity, dysfunctional metabolic signaling pathways, rigid blood–brain …

A simple and highly efficient strategy has been developed for direct C–H trifluoromethylation
at C-3 of imidazopyridines and C-8 of quinoxalines with readily available Langlois reagent …

Simple Summary The aldehyde dehydrogenases enzymes (ALDHs) are promising drug
targets in cancer therapy. ALDHs are members of an enzymatic superfamily composed by …

Cancer stem cells (CSCs), a subpopulation of cancer cells endowed with self-renewal,
tumorigenicity, pluripotency, chemoresistance, differentiation, invasive ability, and plasticity …