Brain tumor related epilepsy: pathophysiological approaches and rational management of antiseizure medication

S Seidel, T Wehner, D Miller, J Wellmer… - … Research and Practice, 2022 - Springer
Background Brain tumor related epilepsy (BTRE) is a common complication of cerebral
tumors and its incidence is highly dependent on the type of tumor, ranging from 10–15% in …

Low-grade epilepsy-associated neuroepithelial tumors: Tumor spectrum and diagnosis based on genetic alterations

M Xie, X Wang, Z Duan, G Luan - Frontiers in Neuroscience, 2023 - frontiersin.org
Brain tumors can always result in seizures when involving the cortical neurons or their
circuits, and they were found to be one of the most common etiologies of intractable focal …

First‐line antiepileptic drug treatment in glioma patients with epilepsy: Levetiracetam vs valproic acid

PB van der Meer, L Dirven, M Fiocco, MJ Vos… - …, 2021 - Wiley Online Library
Objective This study aimed at estimating the cumulative incidence of antiepileptic drug
(AED) treatment failure of first‐line monotherapy levetiracetam vs valproic acid in glioma …

Perampanel confirms to be effective and well-tolerated as an add-on treatment in patients with brain tumor-related epilepsy (PERADET Study)

A Coppola, A Zarabla, A Maialetti, V Villani… - Frontiers in …, 2020 - frontiersin.org
Background: Epilepsy is one of the most common symptoms of brain tumors. It is often drug
resistant and generally worsen patients' quality of life (QoL). Brain tumors release glutamate …

Early postoperative seizures (EPS) in patients undergoing brain tumour surgery

TF Ersoy, S Ridwan, A Grote, R Coras, M Simon - Scientific Reports, 2020 - nature.com
Early postoperative seizures (EPS) are a common complication of brain tumour surgery. This
paper investigates risk factors, management and clinical relevance of EPS. We …

First‐line levetiracetam versus enzyme‐inducing antiseizure medication in glioma patients with epilepsy

PB van der Meer, M Maschio, L Dirven… - …, 2023 - Wiley Online Library
Objective This study aimed to directly compare the effectiveness of first‐line monotherapy
levetiracetam (LEV) versus enzyme‐inducing antiseizure medications (EIASMs) in glioma …

Predictors of postoperative seizure outcome in low grade glioma: from volumetric analysis to molecular stratification

T Ius, G Pauletto, B Tomasino, M Maieron, R Budai… - Cancers, 2020 - mdpi.com
The importance of the extent of resection (EOR) has been widely demonstrated as the main
predictor for survival, nevertheless its effect on tumor related epilepsy is less investigated. A …

Seizures, edema, thrombosis, and hemorrhages: an update review on the medical management of gliomas

M Zoccarato, L Nardetto, AM Basile, B Giometto… - Frontiers in …, 2021 - frontiersin.org
Patients affected with gliomas develop a complex set of clinical manifestations that deeply
impact on quality of life and overall survival. Brain tumor-related epilepsy is frequently the …

Effectiveness and tolerability of lacosamide as add‐on therapy in patients with brain tumor–related epilepsy: Results from a prospective, noninterventional study in …

R Rudà, C Houillier, M Maschio, JC Reijneveld… - …, 2020 - Wiley Online Library
Objective To evaluate the effectiveness and tolerability of lacosamide added to one or two
antiepileptic drugs (AEDs) in the treatment of patients with brain tumor–related epilepsy …

Antitumor potential of antiepileptic drugs in human glioblastoma: Pharmacological targets and clinical benefits

M Stella, G Baiardi, S Pasquariello, F Sacco… - Biomedicines, 2023 - mdpi.com
Glioblastoma (GBM) is characterized by fast-growing cells, genetic and phenotypic
heterogeneity, and radio-chemo-therapy resistance, contributing to its dismal prognosis …