Mobile genetic elements (MGEs) carrying antibiotic resistance genes (ARGs) disseminate
ARGs when they mobilise into new bacterial hosts. The nature of such horizontal gene …

Chimeric antigen receptor (CAR) therapy has achieved remarkable clinical efficacy against
hematological cancers and has been approved by FDA for treatment of B-cell tumors …

Mobile genetic elements (MGEs) are crucial for horizontal gene transfer (HGT) in bacteria
and facilitate their rapid evolution and adaptation. MGEs include plasmids, integrative and …

Escherichia coli Nissle 1917 (EcN) is a probiotic bacterium, commonly employed to treat
certain gastrointestinal disorders. It is fast emerging as an important target for the …

Tigecycline is a last-resort antimicrobial against carbapenemase-producing
Enterobacterales (CPE). However, mobile tigecycline resistance genes, tet (X) and tmexCD …

A key challenge for domesticating alternative cultivable microorganisms with
biotechnological potential lies in the development of innovative technologies. Within this …

Plasmids are autonomously replicating sequences that help cells adapt to diverse stresses.
Theta plasmids are the most frequent plasmid class in enterobacteria. They co-opt two host …

Multiple-replicon resistance plasmids have become important carriers of resistance genes in
Gram-negative bacteria, and the evolution of multiple-replicon plasmids is still not clear …

The high rates of carbapenem resistance among Brazilian Pseudomonas aeruginosa
isolates are mainly associated with the clone ST277 producing the carbapenemase SPM-1 …

Background The strand-biased circularizing integrative elements (SEs) are putatively non-
mobilizable integrative elements for transmitting antimicrobial resistance genes. The …