Elderly individuals are the most susceptible to an aggressive form of coronavirus disease
(COVID-19), caused by SARS-CoV-2. The remodeling of immune response that is observed …

Humans have evolved much longer lifespans than the great apes, which rarely exceed 50
years. Since 1800, lifespans have doubled again, largely due to improvements in …

Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …

Human primary monocytes comprise a heterogeneous population that can be classified into
three subsets based on CD14 and CD16 expression: classical (CD14high/CD16−) …

Human cytomegalovirus (HCMV) infection induces both innate immune responses including
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ …

Several inflammatory biomarkers appear to add to our ability to predict mortality or
opportunistic disease in HIV-infected individuals. Before biomarkers will be useful, it will be …

Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and
specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent …

Purpose: Patients with chronic lymphocytic leukemia (CLL) display immune deficiency that is
most obvious in advanced stage disease. Here we investigated whether this immune …

Exercise training has a profound impact on immunity, exerting a multitude of positive effects
in indications such as immunosenescence, cancer, viral infections and inflammatory …

Background There is reported to be a decline in immune function and an alteration in the
frequency of circulating lymphocytes with advancing age. There are also differences in …