Free‐Boundary Microfluidic Platform for Advanced Materials Manufacturing and Applications

Z Zhu, T Chen, F Huang, S Wang, P Zhu… - Advanced …, 2024 - Wiley Online Library
Microfluidics, with its remarkable capacity to manipulate fluids and droplets at the
microscale, has emerged as a powerful platform in numerous fields. In contrast to …

cGAS‐STING pathway agonists are promising vaccine adjuvants

X Tian, J Ai, X Tian, X Wei - Medicinal Research Reviews, 2024 - Wiley Online Library
Adjuvants are of critical value in vaccine development as they act on enhancing
immunogenicity of antigen and inducing long‐lasting immunity. However, there are only a …

Hybrid systems of nanofibers and polymeric nanoparticles for biological application and delivery systems

HY Vargas-Molinero, A Serrano-Medina… - Micromachines, 2023 - mdpi.com
Nanomedicine is a new discipline resulting from the combination of nanotechnology and
biomedicine. Nanomedicine has contributed to the development of new and improved …

Vinyl sulfone-functionalized acetalated dextran microparticles as a subunit broadly acting influenza vaccine

CJ Batty, LM Lifshits, DA Hendy, M Eckshtain-Levi… - The AAPS journal, 2023 - Springer
Influenza is a global health concern with millions of infections occurring yearly. Seasonal flu
vaccines are one way to combat this virus; however, they are poorly protective against …

Comparative study of acetalated-dextran microparticle fabrication methods for a clinically translatable subunit-based influenza vaccine

ES Pena, CJ Batty, DA Hendy, S Yang… - International Journal of …, 2024 - Elsevier
The most common influenza vaccines are inactivated viruses produced in chicken eggs,
which is a time-consuming production method with variable efficacy due to mismatches of …

Humoral response to the acetalated dextran M2e vaccine is enhanced by antigen surface conjugation

CJ Batty, ES Pena, EA Amouzougan… - Bioconjugate …, 2023 - ACS Publications
The influenza A virus causes substantial morbidity and mortality worldwide every year and
poses a constant threat of an emergent pandemic. Seasonal influenza vaccination strategies …

Sustained delivery of CpG oligodeoxynucleotide by acetalated dextran microparticles augments effector response to Computationally Optimized Broadly Reactive …

CJ Batty, EA Amouzougan, MA Carlock… - International journal of …, 2023 - Elsevier
A subunit or protein-based influenza vaccine can be a safer alternative to live attenuated
vaccine (Flumist) and require fewer boosts than an inactivated vaccine (eg Fluzone) …

Natural extract-polymer monodisperse submicron particles from Plateau-Rayleigh microjets

E Barbero-Colmenar, E Bodnár… - Colloids and Surfaces A …, 2023 - Elsevier
Particles of interest in food, pharmaceutical, and nutraceutical sectors are often formulated
with a polymer and one or more natural or synthetic active compound. The two components …

[HTML][HTML] Multi-COBRA hemagglutinin formulated with cGAMP microparticles elicit protective immune responses against influenza viruses

X Zhang, H Shi, DA Hendy, EM Bachelder, KM Ainslie… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Influenza viruses cause a common respiratory disease known as influenza. In humans,
seasonal influenza viruses can lead to epidemics, with avian influenza viruses of particular …

Comparison of Emulsion and Spray Methods for Fabrication of Rapamycin-Loaded Acetalated Dextran Microparticles

SA Ehrenzeller, NR Lukesh, RT Stiepel… - RSC …, 2024 - pubs.rsc.org
Rapamycin (rapa), an immunosuppressive medication, has demonstrated considerable
effectiveness in reducing organ transplant rejection and treating select autoimmune …