CSF Inflammation Markers Associated with asymptomatic viral escape in Cerebrospinal Fluid of HIV-Positive individuals on antiretroviral therapy

D Guha, V Misra, J Yin, D Gabuzda - Viruses, 2023 - mdpi.com
HIV establishes a viral reservoir in the CNS despite viral suppression in the blood on
antiretroviral therapy (ART). In a minority of people with HIV (PWH), HIV RNA is detectable in …

HIV-Associated Neurocognitive Disorder: A Look into Cellular and Molecular Pathology

LJP Thompson, J Genovese, Z Hong, MV Singh… - International Journal of …, 2024 - mdpi.com
Despite combined antiretroviral therapy (cART) limiting HIV replication to undetectable
levels in the blood, people living with HIV continue to experience HIV-associated …

Serum and CSF biomarkers in asymptomatic patients during primary HIV infection: a randomized study

A Calcagno, J Cusato, P Cinque, G Marchetti… - Brain, 2024 - academic.oup.com
It is debated whether CNS involvement begins during acute human immunodeficiency virus
(HIV) infection in persons without meningitis/encephalitis and whether specific antiretroviral …

Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease

A Lembas, A Załęski, M Peller, T Mikuła… - Cardiovascular …, 2024 - Springer
The developments in HIV treatments have increased the life expectancy of people living with
HIV (PLWH), a situation that makes cardiovascular disease (CVD) in that population as …

Non-classical monocyte levels correlate negatively with HIV-associated cerebral small vessel disease and cognitive performance

MV Singh, MN Uddin, M Covacevich Vidalle… - Frontiers in Cellular …, 2024 - frontiersin.org
Background Despite antiretroviral treatment (cART), aging people living with HIV (PWH) are
more susceptible to neurocognitive impairment (NCI) probably due to synergistic/additive …

Multi-modal analysis of inflammation as a potential mediator of depressive symptoms in young people with HIV: The GOLD depression study

A Mudra Rakshasa-Loots, S Naidoo, T Hamana… - Plos one, 2024 - journals.plos.org
People living with HIV are at three times greater risk for depressive symptoms. Inflammation
is a notable predictor of depression, and people with HIV exhibit chronic inflammation …

Plasma Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers of Cognitive Decline in People Living with HIV

SS Mukerji, P Bachanová, H Park… - The Journal of …, 2024 - academic.oup.com
Background This study examined the relationship between neurofilament light chain (NfL)
and glial fibrillary acidic protein (GFAP) and cognition in people living with HIV (PLWH) at …

CSF Extracellular Vesicle Aβ42 and Tau/Aβ42 Ratio Are Associated with Cognitive Impairment in Older People with HIV

D Guha, V Misra, S Chettimada, J Yin, D Gabuzda - Viruses, 2023 - mdpi.com
HIV-associated neurocognitive disorders (HAND) remain prevalent despite viral
suppression on antiretroviral therapy (ART). Older people with HIV (PWH) are also at risk for …

Characterization of the Proinflammatory Cytokine Profile during Acute SARS-CoV-2 Infection in People with Human Immunodeficiency Virus

A Anzurez, L Runtuwene, TTT Dang… - Japanese Journal of …, 2024 - jstage.jst.go.jp
抄録 Persistent inflammation during chronic human immunodeficiency virus (HIV) infection
may affect the immune response against severe acute respiratory syndrome-coronavirus 2 …

Is it possible to get a two-for-one? Can we slow cognitive decline by treating vascular disease risk factors?

SP Agnihotri, ET Overton - AIDS, 2023 - journals.lww.com
Long-lived organisms, including humans, have adapted to prolong lifespan in the face of a
hostile environment. For humans, two key evolutionary advances facilitating our survival …