Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 (Covid‐19)

Y Zhou, J Chi, W Lv, Y Wang - Diabetes/metabolism research …, 2021 - Wiley Online Library
The outbreak of the coronavirus disease 2019 (Covid‐19) has become an evolving
worldwide health crisis. With the rising prevalence of obesity and diabetes has come an …

Type 2 diabetes and its impact on the immune system

A Berbudi, N Rahmadika, AI Tjahjadi… - Current diabetes …, 2020 - ingentaconnect.com
Introduction: Type 2 Diabetes (T2D) is a major health problem worldwide. This metabolic
disease is indicated by high blood glucose levels due to insufficient insulin production by the …

The effects of type 2 diabetes mellitus on organ metabolism and the immune system

G Daryabor, MR Atashzar, D Kabelitz, S Meri… - Frontiers in …, 2020 - frontiersin.org
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality

LM Frydrych, G Bian, DE O'Lone… - Journal of leukocyte …, 2018 - academic.oup.com
Obesity and type 2 diabetes mellitus (T2D) are global pandemics. Worldwide, the
prevalence of obesity has nearly tripled since 1975 and the prevalence of T2D has almost …

[HTML][HTML] Glycation damage: a possible hub for major pathophysiological disorders and aging

M Fournet, F Bonté, A Desmoulière - Aging and disease, 2018 - ncbi.nlm.nih.gov
Glycation is both a physiological and pathological process which mainly affects proteins,
nucleic acids and lipids. Exogenous and endogenous glycation produces deleterious …

Role of adaptive and innate immunity in type 2 diabetes mellitus

T Zhou, Z Hu, S Yang, L Sun, Z Yu… - Journal of diabetes …, 2018 - Wiley Online Library
After the recognition of the essential role of the immune system in the progression of type 2
diabetes mellitus, more studies are focused on the effects produced by the abnormal …

Diabetes and infection: assessing the association with glycaemic control in population-based studies

J Pearson-Stuttard, S Blundell, T Harris… - The lancet Diabetes & …, 2016 - thelancet.com
Diabetes is a leading cause of morbidity and mortality. The global burden of diabetes is
rising because of increased obesity and population ageing. Although preventive and …

Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections

K Hodgson, J Morris, T Bridson, B Govan, C Rush… - …, 2015 - Wiley Online Library
Diabetes has been recognized as an important risk factor for a variety of intracellular
bacterial infections, but research into the dysregulated immune mechanisms contributing to …

Metabolic dysfunction and immunometabolism in COVID-19 pathophysiology and therapeutics

R Batabyal, N Freishtat, E Hill, M Rehman… - International Journal of …, 2021 - nature.com
The COVID-19 pandemic has emerged as a public health crisis and has placed a significant
burden on healthcare systems. Patients with underlying metabolic dysfunction, such as type …

Glucose metabolism disorder: a potential accomplice of SARS-CoV-2

Y Luan, Y Luan, H He, B Jue, Y Yang, B Qin… - International Journal of …, 2023 - nature.com
Abstract Globally, 265,713,467 confirmed cases of SARS-CoV-2 (CoV-2), including
5,260,888 deaths, have been reported by the WHO. It is important to study the mechanism of …