Neurodevelopmental disorders–including attention‐deficit/hyperactivity disorder (ADHD),
autism spectrum disorder, communication disorders, intellectual disability, motor disorders …

Schizophrenia is a major psychotic disorder with multifactorial etiology that includes
interactions between genetic vulnerability and environmental risk factors. In addition …

Abstract The Human Genome Project was undertaken primarily to discover genetic causes
and better treatments for human diseases. Schizophrenia was targeted since three of the …

With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

Schizophrenia is a highly heritable, severe mental illness characterized by hallucinations,
delusions, social withdrawal, and cognitive dysfunction present in∼ 1% of populations …

The polygenic nature of schizophrenia (SCZ) implicates many variants in disease
development. Rare variants of high penetrance have been shown to contribute to the …

MicroRNAs (miRNAs) play a crucial role in the regulation of gene expression levels and
have been implicated in the pathogenesis of autism spectrum disorder (ASD) and …

Research on serious mental disorders, particularly psychosis, has revealed highly variable
symptom profiles and developmental trajectories prior to illness-onset. As Dante Cicchetti …

Schizophrenia and affective disorder are two major complex mental disorders with high
heritability. Evidence shows that rare variants with significant clinical impacts contribute to …

Background Schizophrenia (SCZ) has a global prevalence of 1% and increases the risk of
mortality, reducing life expectancy. There is growing evidence that the risk of this disorder is …