Dysregulation of gene expression is a frequent occurrence in oral squamous cell carcinoma
(OSCC). However, accumulating evidence suggests that in contrast to genetics, epigenetic …

Head and neck cancer is a collective term that describes malignant tumors of the oral cavity,
pharynx, and larynx characterized by high incidence and mortality rates. Although most …

Background Aberrant nuclear accumulation of proteins influences tumor development and
may predict biologic aggressiveness and disease prognosis. This study determined the …

The relatively modest survival of patients surgically treated for advanced HNSCC can partly
be explained by the development of local relapse. It is important that surgeons are able to …

Silencing of tumor-suppressor genes (TSGs) by DNA promoter hypermethylation is an early
event in carcinogenesis; hence, TSGs may serve as early tumor biomarkers. We determined …

Abstract Background/Aims: The association between cyclin-dependent kinase inhibitor 2A
(CDKN2A) hypermethylation and head and neck squamous cell carcinoma (HNSCC) risk …

Oral squamous cell carcinoma (OSCC) is characterized by high mortality rates. High
incidence of local recurrences in the normal-appearing surgical margins of OSCC patients …

Objectives Earlier studies involving a priori gene selection have identified promoter regions
deregulated by DNA methylation changes in oral squamous cell cancers (OSCCs) and …

Head and neck cancer (HNC) is a heterogenous and complex entity including diverse
anatomical sites and a variety of tumor types displaying unique characteristics and different …

Head and neck squamous cell carcinoma is a heterogeneous group of tumors with each
subtype having a distinct histopathological and molecular profile. Most tumors share, to …