Epidemiological and etiological variations in hepatocellular carcinoma

E Sagnelli, M Macera, A Russo, N Coppola, C Sagnelli - Infection, 2020 - Springer
Background Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer and
a leading cause of cancer-related deaths worldwide. The major risk factors for HCC …

Liver fibrosis: Pathophysiology and clinical implications

J Berumen, J Baglieri, T Kisseleva… - WIREs mechanisms of …, 2021 - Wiley Online Library
Liver fibrosis is a clinically significant finding that has major impacts on patient morbidity and
mortality. The mechanism of fibrosis involves many different cellular pathways, but the major …

Hepatocellular carcinoma in chronic viral hepatitis: where do we stand?

FP Russo, A Zanetto, E Pinto, S Battistella… - International journal of …, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related death.
Although the burden of alcohol-and NASH-related HCC is growing, chronic viral hepatitis …

Hepatocellular carcinoma mechanisms associated with chronic HCV infection and the impact of direct-acting antiviral treatment

S Dash, Y Aydin, KE Widmer… - Journal of hepatocellular …, 2020 - Taylor & Francis
Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …

Hepatic fat—genetic risk score predicts hepatocellular carcinoma in patients with cirrhotic HCV treated with DAAs

E Degasperi, E Galmozzi, S Pelusi, R D'Ambrosio… - Hepatology, 2020 - journals.lww.com
Conclusions In a large cohort of DAA‐treated patients with cirrhotic HCV, GRS was
associated with de novo HCC independently of classical risk factors, including liver disease …

Risk of hepatocellular carcinoma after HCV clearance by direct-acting antivirals treatment predictive factors and role of epigenetics

L Rinaldi, R Nevola, G Franci, A Perrella, G Corvino… - Cancers, 2020 - mdpi.com
Direct-acting antivirals (DAAs) induce a rapid virologic response (SVR) in up to 99% of
chronic hepatitis C patients. The role of SVR by DAAs on the incidence or recurrence of …

Disease progression in patients with hepatitis C virus infection treated with direct-acting antiviral agents

M Mendizabal, F Piñero, E Ridruejo, FH Wolff… - Clinical …, 2020 - Elsevier
Background & Aims Little is known about how a sustained virologic response (SVR) to
treatment of hepatitis C virus infection with direct-acting antivirals (DAAs) affects patient …

Fibrosis stage-specific incidence of hepatocellular cancer after hepatitis C cure with direct-acting antivirals: a systematic review and meta-analysis

NJ Kim, P Vutien, E Cleveland, A Cravero… - Clinical …, 2023 - Elsevier
Background & Aims Hepatitis C virus (HCV) eradication with direct-acting antivirals reduces
hepatocellular carcinoma (HCC) risk. Pooled HCC incidence rates by cirrhosis status and …

Residual risk of liver disease after hepatitis C virus eradication

F Negro - Journal of hepatology, 2021 - Elsevier
Treatment of hepatitis C with direct-acting antivirals is safe and highly efficacious, resulting
in viral clearance (sustained virological response [SVR]) in the vast majority of patients …

Impact of direct‐acting antiviral regimens on mortality and morbidity outcomes in patients with chronic hepatitis C: systematic review and meta‐analysis

Y Sahakyan, V Lee‐Kim, KE Bremner… - Journal of Viral …, 2021 - Wiley Online Library
The long‐term effects of direct‐acting antiviral therapies (DAAs) for chronic hepatitis C
(CHC) remain uncertain. The objective of this systematic review and meta‐analysis was to …