Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …

The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …

Although activity that induced tumor regression was observed and termed tumor necrosis
factor (TNF) as early as the 1960s, the true identity of TNF was not clear until 1984, when …

Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …

Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death
receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized …

Perinatal insults such as hypoxia–ischemia induces secondary brain injury. In order to
develop the next generation of neuroprotective therapies, we urgently need to understand …

Ligands of the tumor necrosis factor superfamily (TNFSF)(4–1BBL, APRIL, BAFF, CD27L,
CD30L, CD40L, EDA1, EDA2, FasL, GITRL, LIGHT, lymphotoxin α, lymphotoxin αβ, OX40L …

The members of the tumour necrosis factor (TNF) superfamily of cytokines play important
roles in the regulation of various immune‐cell functions. Likewise, induction of cell death by …

Fibrosis is the result of extracellular matrix protein deposition and remains a leading cause
of death in USA. Despite major advances in recent years, there remains an unmet need to …

Unlike conventional cancer therapeutics, death receptor ligands trigger tumor cell apoptosis
independently of the p53 tumor suppressor gene, which frequently is inactivated in cancer …