Exosomes and their MicroRNA cargo: new players in peripheral nerve regeneration

L Qing, H Chen, J Tang, X Jia - … and neural repair, 2018 - journals.sagepub.com
Peripheral nerve injury is a major clinical problem and often results in a poor functional
recovery. Despite obvious clinical need, treatment strategies have been largely suboptimal …

Dysfunction of mesenchymal stem cells isolated from metabolic syndrome and type 2 diabetic patients as result of oxidative stress and autophagy may limit their …

K Kornicka, J Houston, K Marycz - Stem cell reviews and reports, 2018 - Springer
Mesenchymal stem cells (MSC) have become a promising tool for therapeutic intervention.
Their unique features, including self-renewal, multipotency and immunomodulatory …

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential

L Qiao, S Hu, S Liu, H Zhang, H Ma… - The Journal of …, 2019 - Am Soc Clin Investig
Exosomes, as functional paracrine units of therapeutic cells, can partially reproduce the
reparative properties of their parental cells. The constitution of exosomes, as well as their …

Exosomes derived from pro‐inflammatory bone marrow‐derived mesenchymal stem cells reduce inflammation and myocardial injury via mediating macrophage …

R Xu, F Zhang, R Chai, W Zhou, M Hu… - Journal of cellular …, 2019 - Wiley Online Library
Exosomes are served as substitutes for stem cell therapy, playing important roles in
mediating heart repair during myocardial infarction injury. Evidence have indicated that …

Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice

R Yue, S Lu, Y Luo, J Zeng, H Liang, D Qin… - Cell death …, 2022 - nature.com
Recent evidence indicates that exosomes derived from mesenchymal stem cells (MSCs)
confer protective effects against myocardial ischemia/reperfusion (I/R) injury. Exosomes are …

[HTML][HTML] Activation of the miR-34a-mediated SIRT1/mTOR signaling pathway by urolithin A attenuates D-galactose-induced brain aging in mice

P Chen, F Chen, J Lei, Q Li, B Zhou - Neurotherapeutics, 2019 - Elsevier
Despite tremendous advances in modern medicine, effective prevention or therapeutic
strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) …

High frequency acoustic cell stimulation promotes exosome generation regulated by a calcium-dependent mechanism

LA Ambattu, S Ramesan, C Dekiwadia… - Communications …, 2020 - nature.com
Exosomes are promising disease diagnostic markers and drug delivery vehicles, although
their use in practice is limited by insufficient homogeneous quantities that can be produced …

Application of human amniotic epithelial cells in regenerative medicine: a systematic review

Q Zhang, D Lai - Stem cell research & therapy, 2020 - Springer
Human amniotic epithelial cells (hAECs) derived from placental tissues have gained
considerable attention in the field of regenerative medicine. hAECs possess embryonic stem …

Exosomes and regenerative medicine: state of the art and perspectives

H Jing, X He, J Zheng - Translational Research, 2018 - Elsevier
Exosomes have attracted the attention of the scientific community in recent years due to their
widespread distribution, their possible functions as biomarkers of disease, and their great …

Exosomal miRNA‐215‐5p Derived from Adipose‐Derived Stem Cells Attenuates Epithelial–Mesenchymal Transition of Podocytes by Inhibiting ZEB2

J Jin, Y Wang, L Zhao, W Zou, M Tan… - BioMed research …, 2020 - Wiley Online Library
Background. Podocyte migration is actively involved in the process of podocyte loss and
proteinuria production, which is closely associated with the development of diabetic …