For more than two decades, the view that tumour-associated matrix metalloproteinases
(MMPs) were required for peritumour tissue degradation and metastasis dominated the drive …

The invasive nature of brain-tumour cells makes an important contribution to the
ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably …

We have previously examined the specificities of 28 commercially available compounds,
reported to be relatively selective inhibitors of particular serine/threonine-specific protein …

Cell migration and invasion are fundamental components of tumor cell metastasis.
Increased focal adhesion kinase (FAK) expression and tyrosine phosphorylation are …

Abdominal aortic aneurysm (AAA) is a common disease among elderly people that, when
surgical treatment is inapplicable, results in progressive expansion and rupture of the aorta …

The lung is affected by a variety of disease processes that can lead to considerable
morbidity and mortality. As the lung is the only organ for respiration and gas exchange, the …

The c-Jun N-terminal protein kinases (JNKs) form one subfamily of the mitogen-activated
protein kinase (MAPK) group of serine/threonine protein kinases. The JNKs were first …

Programmed cell death 4 (Pdcd4) suppresses neoplastic transformation by inhibiting the
activation of c-Jun and consequently AP-1-dependent transcription. We report that Pdcd4 …

The extracellular pH (pHe) of tumor tissues is often acidic, which can induce the expression
of several proteins. We previously showed that production of matrix metalloproteinase-9 …

Protein phosphorylation, while critical to cellular behavior, has been undercharacterized in
pluripotent cells. Therefore, we performed phosphoproteomic analyses of human embryonic …