Targeting post-translational histone modifying enzymes in glioblastoma

E Kunadis, E Lakiotaki, P Korkolopoulou… - Pharmacology & …, 2021 - Elsevier
Glioblastoma (GBM) is the most common primary brain tumor in adults, and the most lethal
form of glioma, characterized by variable histopathology, aggressiveness and poor clinical …

Epigenetic regulation of tumor-immune symbiosis in glioma

Y Liu, H Ali, F Khan, L Pang, P Chen - Trends in Molecular Medicine, 2024 - cell.com
Glioma is a type of aggressive and incurable brain tumor. Patients with glioma are highly
resistant to all types of therapies, including immunotherapies. Epigenetic reprogramming is …

Integrating Multi-Omics analysis for enhanced diagnosis and treatment of glioblastoma: A comprehensive Data-Driven approach

A Barzegar Behrooz, H Latifi-Navid, SC da Silva Rosa… - Cancers, 2023 - mdpi.com
Simple Summary The most prevalent and lethal primary brain tumor, glioblastoma
multiforme (GBM), exhibits fast growth and widespread invasion and has a poor prognosis …

Chidamide inhibits glioma cells by increasing oxidative stress via the miRNA‐338‐5p regulation of hedgehog signaling

H Zhou, L Han, H Wang, J Wei… - Oxidative Medicine and …, 2020 - Wiley Online Library
Objective. Chidamide has a broad spectrum of antitumor activity but its function on glioma
remains unknown. The increase of reactive oxygen species (ROS) and reactive nitrogen …

A selective histone deacetylase inhibitor induces autophagy and cell death via SCNN1A downregulation in glioblastoma cells

HH Chang, YY Chang, BC Tsai, LJ Chen, AC Chang… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma multiforme (GBM) patients have a poor prognosis. Recent
literature has shown that GBM treatment is challenging, mainly due to the heterogeneity of …

[HTML][HTML] Expression and prognostic analyses of HDACs in human gastric cancer based on bioinformatic analysis

L Chen, Y Fei, Y Zhao, Q Chen, P Chen, L Pan - Medicine, 2021 - journals.lww.com
Gastric cancer (GC) is a common cancerous tumor, and is the third leading cause of cancer
mortality worldwide. Although comprehensive therapies of GC have been widely used in …

Deciphering the Mysterious Relationship between the Cross-Pathogenetic Mechanisms of Neurodegenerative and Oncological Diseases

Y Aleksandrova, M Neganova - International Journal of Molecular …, 2023 - mdpi.com
The relationship between oncological pathologies and neurodegenerative disorders is
extremely complex and is a topic of concern among a growing number of researchers …

[HTML][HTML] Comprehensive analysis of histone deacetylases genes in the prognosis and immune infiltration of glioma patients

L Shen, Y Li, N Li, L Shen, Z Li - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
The occurrence and development of tumors are closely related to histone deacetylases
(HDACs). However, their relationship with the overall biology and prognosis of glioma is still …

[HTML][HTML] The Role of HDAC6 in Glioblastoma Multiforme: A New Avenue to Therapeutic Interventions?

F Spallotta, B Illi - Biomedicines, 2024 - mdpi.com
Despite the great advances in basic research results, glioblastoma multiforme (GBM) still
remains an incurable tumour. To date, a GBM diagnosis is a death sentence within 15–18 …

Targeting epigenetic dependencies in solid tumors: evolutionary landscape beyond germ layers origin

F Citron, L Fabris - Cancers, 2020 - mdpi.com
Extensive efforts recently witnessed the complexity of cancer biology; however, molecular
medicine still lacks the ability to elucidate hidden mechanisms for the maintenance of …